Cover Feature: Genetic Encoding of a Bioconjugation Handle for [2+2+2] Cycloaddition Reactions (ChemBioChem 3/2020)
نویسندگان
چکیده
منابع مشابه
A Review on 1,3-dipolar Cycloaddition Reactions in Bioconjugation and It’s Importance in Pharmaceutical Chemistry
1,3-dipolar Cycloaddition (DC) reactions have emerged as one of the important type of cycloaddition reactions from the view point of chemical and biological industry. Particularly the Azide-Alkyne Cycloaddition, also known as “Click Chemistry” has opened up new challenges in front of medicinal and pharmaceutical chemists. Bioconjugation is a technique of coupling two different biomolecules by c...
متن کاملCycloaddition reactions of unsaturated sulfones
The reaction of a series of allyl-substituted bis(phenylsulfony1)methanes or dimethyl malonates with 2,3-bis(phenylsulfonyl)l13-butadiene in the presence of base afforded alkenyl-substituted allenes in good yield. The reaction proceeds by initial attack of the soft carbanion onto the terminal position of the diene and subsequent PhS02elimination to give the phenylsulfonyl substituted allene. Th...
متن کاملComputational study of cycloaddition reactions
Cycloaddition reactions between 1,3-butadiene and the C-terminated SiC(1 0 0)-c(2 · 2) surface have been addressed using quantum-chemical methods. The c(2 · 2) structure consists of ACBCA bridges between underlayer Si atoms which themselves form SiASi bonds. Of various possible reaction products, the one formed by a [2+ 4] reaction with the ACBCA bridge (giving a species resembling 1,4-cyclohex...
متن کاملA novel synthesis of diastereomerically pure spiro- oxindolopyrrolizidines and oxindolopyrrolidines via cycloaddition reactions of azomethine ylides
An efficient one-pot three-component procedure for the synthesis of new chiral spiro oxindolopyrrolidines/pyrrolizidines with highly regio- and diastereo-enantio, selective from 1,3-dipolar cycloaddition of azomethine ylides and chiral menthol-drived trans-cinnamic are described. The mechanism of the reaction is discussed on basis of the assignment of the absolute configuration of one of the cy...
متن کاملTheoretical studies on cycloaddition reactions
Cycloaddition reactions represent one of the most powerful processes in organic chemistry. The most common types of cycloaddition reactions are the Diels-Alder (DA) and the 1,3-dipolar cycloaddition reactions (1,3-DCs) which lead to five and six membered rings, respectively. In our ongoing efforts to contribute to the understanding of DA and 1,3-DCs; we studied the following using the B3LYP/6-3...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2020
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.202000012